Serotonin transporter promoter single nucleotide polymorphism susceptibility to chemotherapy-induced nausea and vomiting in colorectal cancer
10.3969/j.issn.1006-5725.2018.06.019
- VernacularTitle:5-羟色胺转运体基因启动子区单核苷酸多态性与结直肠癌化疗致恶心呕吐的易感性
- Author:
Yisheng WEI
1
;
Yaguang ZHOU
;
Qiwen WANG
;
Xiao ZHANG
;
Minrui LUO
Author Information
1. 广州医科大学附属第二医院胃肠外科
- Keywords:
colorectal cancer;
serotonin transporter;
single nucleotide polymorphism;
chemotherapy;
nausea and vomiting
- From:
The Journal of Practical Medicine
2018;34(6):949-952,957
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the susceptibility of serotonin promoter single nucleotide polymorphism (SNP)rs956304 to chemotherapy-induced nausea and vomiting(CINV)in colorectal cancer.Methods Rs956304 genotypes and the clinical pathological data of 166 patients with colorectal cancer from September 2009 to April 2014 were retrospectively analyzed. Rs956304 genotype was analyzed by sequencing. The correlations between rs956304 genotype,factors of clinical pathology and CINV were analyzed by chi-square test. Unconditional logistic regression model was used to analyze the independent effect of rs956304 genotype on colorectal cancer CINV. Results Chi-square test showed that moderate to severe CINV was associated with rs956304 AG+GG genotype (P=0.011). Unconditional logistic regression model showed that the patients with AG+GG genotype had a signifi-cant higher risk of moderate to severe CINV than AA genotype(OR=3.215,95% CI:1.202 to 8.599,P=0.020). Conclusion Rs956304 AG+GG genotype is an independent risk factor for moderate to severe colorectal cancer CINV.
