Protective effects of Rheum officinale Ball. as a main agent in a traditional Chinese medicine recipe com-bined with sequential hemoperfusion in patients with acute paraquat poisoning
10.3969/j.issn.1006-5725.2018.05.037
- VernacularTitle:大黄为主中药组方联合持续血液灌流对百草枯中毒患者的保护作用
- Author:
Guoying MA
1
;
Hongna QI
;
Qingmian XIAO
;
Xun GAO
;
Baoyue ZHU
;
Wei LI
;
Yongjian LIU
;
Pu WANG
;
Weizhan WANG
Author Information
1. 河北医科大学附属哈励逊国际和平医院急救医学部 河北衡水 053000
- Keywords:
acute paraquat poisoning;
type Ⅲ procollagen peptide;
traditional Chinese medicine;
hemoperfusion;
pulmonary fibrosis;
oxidative stress
- From:
The Journal of Practical Medicine
2018;34(5):847-850
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical value of Rheum officinale Ball.as a main agent in a tra-ditional Chinese medicine recipe combined with continuous hemoperfusion in patients with acute paraquat poison-ing(APP). Methods A total of 124 patients with APP were divided into three groups:A group(40 cases),B group(42 cases)and C group(42 cases). Before,3 days and 7 days after treatment,PⅢNP,CⅣ,TGF-β1, MDA,SOD and SOFA scores were observed. The correlation between PⅢNP and the concentration of paraquat were analyzed,and the outcomes in 28 days were compared.Results In admission,there were no differences in PⅢNP,CⅣ,TGF-β1,MDA,SOD and SOFA scores among three groups(P>0.05).After treatment for 3 days, MDA and SOFA scores were elevated in three groups compared with these three scores in the three groups at admis-sion. Group A was increased significantly;the activity of SOD were decreased,especially in A group decreased most significantly(P<0.05);After 7 days'treatment,MDA and SOFA scores were lower than those of 3 days af-ter treatment in three groups,especially in C group decreased most significantly(P < 0.05),the activity of SOD were higher than 3 days after treatment,especially in C group increased most significantly(P<0.05);After 3,7 days treatment,PⅢNP,CⅣ,TGF-β1 were increased gradually,C group increased slowly(P<0.05).PⅢNP in patients with APP was positively correlated with the concentration of paraquat(P < 0.05). The mortality rate of three groups were 65.00%,45.24%and 23.81%,there were significant difference among three groups(P<0.05). Conclusions Rheum officinale Ball.as a main agent in a traditional Chinese medicine recipe combined with con-tinuous hemoperfusion in patients with APP could decrease PⅢNP,CⅣ,TGF-β1 and MDA. The can enhance the expression of SOD and reduce the mortality rate of patients.
