Clinicopathological characteristics and survival of 1912 female breast cancer patients with different HER-2
10.3969/j.issn.1006-5725.2018.05.035
- VernacularTitle:新疆1912例女性不同HER-2状态乳腺癌患者临床病理特征和生存分析
- Author:
Yadong PENG
1
;
Ning LIU
;
Fang CHENG
Author Information
1. 新疆医科大学附属肿瘤医院特需科 乌鲁木齐 830011
- Keywords:
breast cancer;
human epidermal growth factor receptor 2;
clinicopathological characteris-tics;
prognosis
- From:
The Journal of Practical Medicine
2018;34(5):836-841
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinicopathological characteristics and prognosis of female breast cancer patients with different human epidermal growth factor receptor 2(HER-2)in Xinjiang. Methods The rela-tionships between the expressions and clinical pathology and prognosis of 1,912 female breast cancer patients with HER-2A were retrospectively analysed. Results Distant metastasis rate,3-year overall survival(OS)and 3-year progression-free survival(PFS)in the HER-2 positive breast cancer patients were all significantly higher than in the HER-2 negative breast cancer patients(P<0.05).3-year OS in the patients with targeted therapy patients was higher than in those without targeted therapy among those HER-2 positive patients. Multivariate analysis revealed that HER-2,endocrine therapy,chemotherapy and targeted therapy were the independent prognostic factors of OS and PFS. Vessel tumor thrombus,tumor diameter,lymph node conditions were the independent prognostic factors of OS and race was the independent prognostic factor of PFS. Conclusion The main type of breast cancer in Xin-jiang is invasive ductal carcinoma,with a positive rate of HER-2 expression 30.9%.A younger age trend comes up in diagnosis.HER-2 status,endocrine therapy,chemotherapy and targeted therapy may provide important informa-tion for the prognosis of breast cancer.Race is the independent prognostic factor of PFS.
