A clinical study on nasal atomization of budesonide combined with hypertonic saline
10.3969/j.issn.1006-5725.2018.05.022
- VernacularTitle:高渗盐水联合布地奈德经鼻雾化治疗儿童呼吸道过敏性疾病临床疗效
- Author:
Jianping CHEN
1
;
Fangming XU
;
Tingting ZHU
;
Ling WANG
;
Chunmei LIU
;
Wei JIANG
;
Hui CHEN
;
Xueying ZHANG
Author Information
1. 上海市徐汇区大华医院儿科 上海200237
- Keywords:
hypertonic saline;
budesonide;
nasal atomization;
combination therapy
- From:
The Journal of Practical Medicine
2018;34(5):782-786
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical efficacy of respiratory allergic diseases in children treated by nasal atomization of budesonide combined with 3% hypertonic saline. Methods Children diagnosed as upper air-way cough syndrome or mild to moderate asthma without being controlled by anti-asthma treatment were included in the study.They contracted with complications of nasal congestion and/or running noseand other symptoms,and na-sal CT confirmed the nasal lesions.Thirty children undergoing conventional treatment(conventional drug therapy+keeping away from allergen)were defined as the control group. 89 children treated with nasal spray therapy(con-ventional drug therapy + keeping away from allergen + nasal spray treatment)were defined as the therapy group. The treatment group was subdivided into IgE-mediated group and non-IgE-mediated group according to IgE level. The treatment course was 7 days.The clinical symptoms score,nasal symptom visual scale(VAS),peak expirato-ry flow(PEF)index were observed and analyzed. Results The clinical symptom score and nasal VAS showed a decreasing trend and the percentage of PEF showed an increasing trend in the two groups within 1 week after treat-ment.The clinical symptom score and nasal VAS score of the treatment group were significantly lower than those of the control group,while the PEF%value was significantly higher.The difference in treatment method was interact-ed with the treatment time(P<0.05).The percentage of PEF in the non-IgE-mediated group was significantly high-er than that of IgE-mediated group 1 week after treatment(P < 0.05). Conclusion The nasal atomization of budesonide combined with hypertonic saline in the treatment of children with respiratory allergic diseases is effec-tive and of a good clinical value.
