Expression of TRIM28 and p16 in esophageal squamous cell carcinoma and their clinicopathological signifi-cance
10.3969/j.issn.1006-5725.2018.05.017
- VernacularTitle:食管鳞癌组织中TRIM28和p16的表达与临床病理因素的关系
- Author:
Wei SUN
1
;
Bo LIU
;
Xiujuan LI
;
Kun LI
;
Yuanyuan LIN
;
Yang L(U)
;
Fengyu LI
Author Information
1. 河北北方学院 组织学与胚胎学教研室 河北张家口 075000
- Keywords:
esophageal squamous cell carcinoma;
TRIM28;
p16;
immunohistochemistry;
immuno-fluorescence
- From:
The Journal of Practical Medicine
2018;34(5):760-764
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of TRIM28 and p16 in esophageal squamous cell car-cinoma(ESCC)and explore the possible correlation with them and clinicopathological characteristics. Methods The expression level of TRIM28 and p16 were measured by immunohistochemistry S-P in 136 cases with ESCC and 37 cases with normal esophageal mucosa,selected from the First Affiliated Hospital of Hebei North University De-partment of Pathology.The relationship between them and the clinical-pathological features was also analyzed.The localization of TRIM28 and p16 protein in ESCC was detected by immunofluorescence. Results(1)The positive rates of TRIM28 and p16 in ESCC were 91.2%and 32.4%,respectively,whereas in normal esophageal mucosa the corresponding rates were 24% and 57%,respectively.(2)Immunofluorescence results showed that TRIM28 and p16 protein were all mainly distributed in the nucleus of ESCC.(3)The abnormal expression of TRIM28 and p16 protein were all related to the invasion depth,TNM staging and lymph node metastasis in ESCC(P < 0.05).(4) The expression of TRIM28 was negatively correlated to the expression of p16 in ESCC(r =-0.284,P = 0.001). Conclusions The abnormal expression of TRIM28 and p16 may have synergistic effect on the initiation and devel-opment of ESCC.Co-detection of the expression of them may be useful for diagnosis of ESCC and guiding the clini-cal therapy.
