Protective effect of permissive hypercapnia in infants undergoing one-lung ventilation
10.3969/j.issn.1006-5725.2018.05.011
- VernacularTitle:允许性高碳酸血症策略在婴儿单肺通气中的肺保护作用
- Author:
Yongle LI
1
;
Hui LUO
;
Wei HUANG
;
Haiyang LI
;
Mingyang CAI
;
Kunwei LI
;
Zurong HU
;
Jing LIU
Author Information
1. 广东省妇幼保健院 广州510010
- Keywords:
hypercapnia;
one-lung ventilation;
infant;
lung protection;
oxygenation
- From:
The Journal of Practical Medicine
2018;34(5):734-737,741
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effect of permissive hypercapnia in infants undergoing one-lung ventilation(OLV). Methods A total of 64 infants were randomly divided into Group N(normocapnia group,n=32)and Group H(hypercapnia group,n=32).Arterial blood gas samples were collected at four differ-ent time points:10 minutes after intubation(T1),30 and 60 minutes after artificial pneumothorax(T2,T3),and 30 minutes after being sent to post anesthesia care unit(T4)while vital signs(HR,MAP,SpO2and temperature) and ventilation parameters(Ppeak,Vt,PEEP,RR,MVV,and FiO2)were recorded simultaneously;OI was calcu-lated by corresponding equation. Bronchoalveolar lavage fluid(BALF)was collected before and after surgery for the measurement of RAGE. Results Compared with those at T1,MAP and PaO2were significantly lower but Ppeak was obviously higher in group N,while HR,Ppeakas well as PaCO2were increased(P<0.05)and Vt,MVV,pH, PaO2as well as lactic acid were decreased in group H(P < 0.05)at T2and T3. Compared with those in group N, MAP,HR as well as PaCO2were higher while Ppeak,Vt,MVV,pH,and lactic acid were lower in group H at T2 and T3(P<0.05).There was a significant increase of RAGE in both groups after surgery and it was much higher in group N when compared with that in group H after surgery(P<0.05). Conclusion PHC not only has advantages in improving tissue oxygenation,but also has the potential of lung protection for infants undergoing OLV.
