Effects of Niaoduqing Granule on quality of life and TGF- β1/Smad signalling in chronic renal failure rats received peritoneal dialysis
10.3969/j.issn.1006-5725.2018.05.009
- VernacularTitle:尿毒清颗粒对慢性肾衰竭腹膜透析大鼠生存质量及TGF-β1/Smad通路表达的影响
- Author:
Jinxiu CHENG
1
;
Junrong HAO
;
Linlin WANG
;
Cuilan LIU
;
Xing PAN
;
Sheng-Jun LIU
;
Hua LIU
Author Information
1. 河北北方学院附属第一医院肾内科 河北张家口075000
- Keywords:
Niaoduqing Granule;
peritoneal dialysis;
quality of life;
transforming growth factor beta 1;
phosphorylated Samd2/3 protein
- From:
The Journal of Practical Medicine
2018;34(5):725-728
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Niaoduqing Granule on the quality of life and the activa-tion of TGF-β1/Smad signalling in chronic renal failure rats received peritoneal dialysis. Methods Thirty SD rats were used to establish peritoneal dialysis models and were randomly divided into the model group(group M),the low dose group(group L),and the high dose group(group H).The dosage of group L and group H was 2 and 4 g/(kg·d),respectively. The body mass,the number of independent activities,the index of renal hypertrophy, Scr,BUN,experssion of TGF-β1 and p-Samd2/3 were determined. Results The body weight growth rate was shown decreased as follows:group N>group H>group L>group M.The number of spontaneous activity of group M decreased significantly than those in other groups. Scr,BUN and kidney hypertrophy index were significantly different among the four groups.Compared with group M,BUN,Scr,kidney hypertrophy index,levels of TGF-β 1 and p-Samd2/3 were significantly decreased in group L and H. Levels of TGF-β1 and p-Samd2/3 were signifi-cant different between group L and H. Conclusions Niaoduqing Granule can improve the quality of life and re-duce the level of serum creatinine and urea nitrogen in chronic renal failure rats received peritoneal dialysis,and the mechanism may be associated with the regulation of TGF-β1/Smad signaling pathway.
