Study on reconstruction of rabbit alveolar bone defect with strontium-containing brushite bone ce-ments
10.3969/j.issn.1006-5725.2018.05.008
- VernacularTitle:掺锶透钙磷石骨水泥修复骨质疏松家兔牙槽骨缺损的实验研究
- Author:
Jun FANG
1
;
Wei DONG
;
Hongfeng PENG
;
Yanli XU
;
Wanping JIA
;
Lishuo LIANG
;
Yongqiang LIANG
Author Information
1. 华北理工大学口腔医学院 正畸科 河北唐山063000
- Keywords:
strontium-containing brushite;
osteoporosis;
bone defect;
basic fibroblast growth factor
- From:
The Journal of Practical Medicine
2018;34(5):720-724
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate whether 5% strontium-containing brushite bone cements(DCPD) has repair effect on alveolar bone defects in osteoporotic rabbits. Methods Eighteen healthy adult female rabbits were used to establish osteoporosis models and were randomly divided into three groups:the blank control group, DCPD group,doped 5%DCPD group(5%strontium),with 6 rats in each group.In addition to the blank group, rats the other groups were filled with the corresponding bone cements in the bilateral alveolar bone defects. At 4 weeks and 8 weeks after operation,3 rats in each group were killed and given shooting the defect area X-ray.The expression of b-FGF was detected by immunohistochemistry. Results X-ray results showed that the defected of doped 5% DCPD group have been nearly completedat the 8 week,DCPD group partially completed repair,but blank group was not fully repaired. The results of immunohistochemistry showed that the expression of b-FGF was the highest at 4 weeks and decreased at 8 weeks after operation.Expression of b-FGF was significantly different at 4 weeks and 8 weeks among the three groups.Conclusion The 5%strontium-containing brushite bone cements can repair bone defect in osteoporotic rabbits.
