Expressions of DCX and GAP-43 in the hippocampal dentate gyrus of offspring rats after maternal expo-sure to acrylamide

VernacularTitle:丙烯酰胺母源性暴露对仔鼠海马齿状回DCX和GAP-43表达的影响
Author: Dehui YANG ¹ ; Shengmin LAI ; Ziting GU ; Hongqing LIU ; Yuxin MA ; Li LUO ; Guoying LI ; Jing LIU
Author Information

1. 广东药科大学基础学院人体解剖学教研室广州510006
Keywords: acrylamide; hippocampal dentate gyrus; doublecortin; growth associated protein-34
From: The Journal of Practical Medicine 2018;34(5):717-719,724
CountryChina
Language:Chinese
Abstract: Objective To investigate the neurodevelopmental toxicity of ACR by studying the expression of DCX and GAP-43 in the hippocampal dentate gyrus of rats after maternal exposure to acrylamide. Methods Pregnant rats were randomly divided into low-dose ACR(4.5 mg/kg),medium-dose(9 mg/kg),high dose groups(18 mg/kg)and the control group(0 mg/kg),8 in each group,and were exposed to toxicant from gestation-al day 15 to postnatal day 13. All rats and their pups were killed on postnatal day 14. ABC immunohistochemistry was used to detect the expression of GFAP in the hippocampus of mother rats and offspring. Results Compared with the control group,the expression of DCX and GAP-43 in hippocampus dentate gyrus of the pregnant rats in middle and high dose groups was significantly decreased(P < 0.05). Conclusion ACR may interfere with the growth and development of neurons by reducing the expression of DCX and GAP-43.