Clinical significance of exhaled breath condensate and serum 8-isoPG MPO,LTB4 and IL-6 in patients with bronchial asthma and chronic obstructive pulmonary disease overlap syndrome
10.3969/j.issn.1006-5725.2018.04.032
- VernacularTitle:支气管哮喘-慢性阻塞性肺疾病重叠综合征患者呼出气冷凝液和血清8-isoPG、MPO、LTB4、IL-6的测定及临床意义
- Author:
Xiaoming XIONG
1
;
Guoqiang TONG
;
Yunjie FU
;
Xueli CHEN
;
Qi XIANG
;
Yubing JI
;
Ruiming CHENG
Author Information
1. 九江市第一人民医院呼吸内科 江西九江332000
- Keywords:
ACOS;
EBC;
8-isoPG
- From:
The Journal of Practical Medicine
2018;34(4):649-652
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significance of biochemical markers in EBC and serum in patients with bronchial asthma and chronic obstructive pulmonary disease overlap syndrome(ACOS). Methods We selected Patients with chronic airway inflammatory diseases in our hospital,These patients underwent clinical trial after the stable phase,including 18 ACOS patients,22 asthma patients,24 COPD patients and 20 healthy non-smokers in the same period.8-isoPG and other inflammatory factors levels in EBC and serum were measured in the selected patients. A comparative analysis was performed. Results The levels of EBC 8-isoPG in the ACOS group were significantly higher than those in the healthy control group,The levels of serum and EBC 8-isoPG in the ACOS group were significantly higher than the asthma group and the COPD group(P < 0.05). The level of 8-isoPG in EBC was not related to age,smoking index,weight,and FEV1value(P>0.05).Conclusions Inflam-matory factors including 8-isoPG,are involved in chronic inflammation in lung tissues of patients with ACOS. 8-isoPG in EBC may have potential value in identifying ACOS from COPD and asthma as biomarkers and deserve further study.
