Clinical significance of dynamic detecting TNF-α,HMBG-1,TF and vWF in peripheral blood from patients with sepsis
10.3969/j.issn.1006-5725.2018.04.027
- VernacularTitle:脓毒症患者外周血TNF-α、HMGB-1、TF和vWF动态变化及临床意义
- Author:
Xinglong MA
1
;
Yang JIANG
;
Jiaxin LI
;
Qianru HANG
;
Zhuoji WANG
;
Qingmeng LIU
Author Information
1. 遵义市第一人民医院重症医学科 563002贵州遵义
- Keywords:
sepsis;
TNF-α;
HMBG-1;
TF;
vWF;
dynamic detecting
- From:
The Journal of Practical Medicine
2018;34(4):630-633
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significance of dynamic detecting the levels of TNF-α, HMBG-1,TF and vWF in the peripheral blood from the patients with sepsis. Method The serum and plasma were collected from 39 patients with sepsis onset 24,48,72 and 120 h,and 15 health volunteers. The levels of TNF-α,HMBG-1,TF in serum and vWF in plasma were detected with ELISA.The septic patients were divided in-to death and survival groups.The relations were compared between the changes of the levels of TNF-α,HMBG-1, TF and vWF from septic patient peripheral blood with the illness severity.Results The levels of TNF-α,HMBG-1, TF and vWF in serums from different time point septic patient were significantly higher than health group(P <0.01).The peak time was 24 h for TNF-α,48 h for HMBG-1,TF and vWF,and the 24 h was lowest.By the mul-tivariate Logistic regression analysis,the death groups were significantly higher than survival groups(P < 0.05 &0.01).By ROC curve analysis,the 4 inflammatory factors have obvious judgment value from 72 and 120 h curves. Conclusion Firstly,the inflammatory immune response in the septic patient was excessive activated. Then the levels of detected inflammatory factors have a trend toward increased with the extension of the course and there may be a peak point. Moreover,the levels of detected inflammatory factors have a positively correlated with the course of the disease.Lastly,by dynamic detecting the changes of the levels of TNF-α,HMBG-1,TF and vWF in serum from septic patient,it can be served as a comprehensive evaluation index of the patient condition,treatment effect and prognostic judgment.
