Clinical analysis and serotypes distribution of neonatal purulent meningitis caused by group B streptococcus
10.3969/j.issn.1006-5725.2018.04.021
- VernacularTitle:新生儿B族链球菌脑膜炎的临床特征和血清分型
- Author:
Juan LI
1
,
2
;
Kankan GAO
;
Lanlan ZENG
;
Sufei ZHU
;
Qiulian DENG
;
Xia HUA
;
Huamin ZHONG
;
Yan LONG
;
Xiurong GAO
;
Haiying LIU
Author Information
1. 广州医科大学附属肿瘤医院检验科 广州510070
2. 广州市妇女儿童医疗中心检验科 广州510623
- Keywords:
infant;
purulent meningitis;
group B streptococcus;
serotypes distribution;
drug sensitivity
- From:
The Journal of Practical Medicine
2018;34(4):609-612
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical characteristics,antibiotic susceptibilities and serotypes of Group B Streptococcus(GBS)isolated from neonatal meningitis to provide references for the prevention and treatment of neonatal GBS meningitis. Methods From June 2013 to June 2016,we surveyed the GBS strains iso-lated from purulent meningitis of < 90 days infants from Guangzhou Women and Children′s Medical Center. The GBS isolates were identified and the minimum inhibitory concentration of the antibiotics was determined by Vitek 2 Compact automatic bacterial identification system.GBS serotyping was performed using Strep-B-Latex?rapid latex agglutination test kit. Results A total of 46 cases of neonatal GBS meningitis,15 cases of early-onset infection and 31 cases of late-onset infection were diagnosed. 78.3% of GBS meningitis with varying degrees of complica-tions.Among 41 survivors with 3~24 months follow-up,50% of the early-onset and 44.8% of the late-onset GBS meningitis with varying degrees of neurological sequelae.Four capsular types were identified among the 46 isolates, serotype-Ⅲwas the most prevalent(73.9%),followed by Ib(19.6%),V(4.3%)and Ia(2.2%).All the isolates were susceptible to penicillins,cephalosporins,linezolid and vancomycin. Conclusion The highly pathogenic serotype-Ⅲ was the predominant serotype among neonatal GBS meningitis in Guangzhou,Therefore,it is neces-sary to strengthen the epidemiological surveillance of GBS invasive infection and the effective implementation of pre-ventive measures.
