Effects of goal-directed fluid therapy on inflammatory cytokines under combined anesthesia
10.3969/j.issn.1006-5725.2018.04.020
- VernacularTitle:联合麻醉下目标导向液体治疗对炎症细胞因子的影响
- Author:
Wei-Jia CHEN
1
;
Shubo ZHANG
;
Chaojie YANG
;
Baoyong LI
;
Ping GAO
Author Information
1. 华北理工大学附属医院麻醉科 河北唐山063000
- Keywords:
goal-directed fluid therapy;
inflammatory cytokines;
stroke volume variation
- From:
The Journal of Practical Medicine
2018;34(4):604-608
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate effects of goal-directed fluid therapy on inflammatory cytokines under combined anesthesia.Methods 60 patients undergoing colorectal cancer surgery,aged 60 to 85 years old,which were classified as American Society of Anesthesiology(ASA)classⅡ~Ⅲ,were randomly assigned to Goal-directed fluid therapy group(group G,n = 30)and central venous pressure liquid management group(group C,n = 30). Life sign and BIS indexes were collected at the time points,before surgery(T1),after the start of the operation (T2),one hour after surgery(T3),after the operation(T4).Hemodynamic indexes were recorded.Two milliliter blood sample were phlebotomized for evaluation of TNF-α and IL-6 from each patient at T1,T3,T4.The infusion volume, the amount of bleeding,the operation time,anal exhaust time,and length of postoperative hospital stay were recorded. Results Comparing information between the two groups,infusion volume and colloid had an obvious decrease than that of group C(P<0.05).SVV and CVP of group G were much stable than group C.The levels of TNF-α and IL-6 of group G were lower than those of group C(P<0.01).The length of anal exhaust time and post-operative hospital stay group G were faster than that of group C(P<0.01).Conclusions Goal-directed fluid ther-apy is superior on fluid administration. It can reduce the release of IL-6 and TNF-α. It is beneficial to elderly colorectal cancer patients with hypertension.
