Clinical significance of PCT,DD,and CRP levels in patients with infection in acute-on-chronic liver fail-ure
10.3969/j.issn.1006-5725.2018.03.017
- VernacularTitle:降钙素原、D-二聚体、C-反应蛋白对慢加急性肝衰竭患者并发感染的临床意义
- Author:
Liming TAN
1
;
Yimei MENG
;
Tingting LONG
;
Xiaolin GUAN
;
Sifan WU
;
Wei ZHENG
;
Huiying FU
;
Qiaohua WANG
;
Yang WU
;
Tingting ZENG
;
Yongjian TIAN
;
Jianlin YU
;
Juanjuan CHEN
;
Hua LI
;
Lip-Ing CAO
;
Hui XU
Author Information
1. 南昌大学第二附属医院检验科
- Keywords:
acute-on-chronic liver failure;
infection;
procalcitonin;
D-dimer;
C-reactive protein
- From:
The Journal of Practical Medicine
2018;34(3):410-415
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical diagnostic value of serum procalcitonin(PCT),D-dimer (DD),C-reactive protein(CRP)in acute-on-chronic liver failure(ACLF). Methods 124 ACLF patients, 63 chronic hepatitis B patients,32 chronic hepatitis C patients,24 chronic hepatitis E patients and 60 healthy controls from the second affiliated hospital of Nanchang University were enrolled in this study.PCT was detected by a sandwish immunodetection method. D-dimer was detected by Latex Turbidimetry. CRP was detected by rate nephenometry. The detection results were used for analyzing the clinical diagnostic value of ACLF with infection. Results(1)The level of PCT,DD and CRP in ACLF group were significantly higher than non-ACLF group and healthy controls(P<0.05).The levels of PCT,DD and CRP in the infection group were significantly higher than non-infection group(P<0.05).(2)The positive rates of PCT,DD and CRP in the infection group were 93.24%, 78.38%,89.19%,which were significantly higher than the non-infection group and healthy controls respectively (P < 0.05).(3)The sensitivity(93.24%)and specificity(90.00%)of PCT were the highest among all indexes. (4)The area under the ROC curve of PCT,DD,CRP were 0.892,0.715,0.755,respectively.PCT had the highest diagnostic value. Conclusion The levels of serum PCT,DD and CRP have a significant clinical value for the early diagnosis of ACLF with infection.
