Experimental study on the effect of sulfotanshinone sodium in lung fibrosis by oleic acid in ALI rats
10.3969/j.issn.1006-5725.2018.03.007
- VernacularTitle:丹参酮Ⅱ-A磺酸钠对大鼠油酸致急性肺损伤纤维化的干预效应
- Author:
Zhiping LIU
1
;
Li LUO
;
Fenying LI
;
Yuanbin CHEN
;
Shaoping QIN
;
Ming HE
;
Zhaozhi ZENG
;
Minghua ZHENG
Author Information
1. 广东药科大学附属第二医院(广州新海医院) 广州510300
- Keywords:
ALI;
sulfotanshinone sodium;
fibrosis;
effect;
inflammatory cytokines
- From:
The Journal of Practical Medicine
2018;34(3):367-370
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect and mechanism of sulfotanshinone sodium in lung fibrosis in ALI rats by intraperitoneal injection. Method The rats were divided into normal group,model group and sulfotan-shinone sodium group randomly.During the experiment,acute lung injury was induced by oleic acid in rats.Sulfo-tanshinone sodium group was treated by intraperitoneal injection of sulfotanshinone sodium for 14 days consecutively. The 12 rats were sacrificed at 7thand 14thday after last administration.The indexes of weight,arterial partial pres-sure of oxygen(PaO2),oxygenation index(PaO2/FiO2),lung index and wet/dry ratio,IL-1,TNF-α,PCⅢ,TGF-β1 and the lung histopathology of rats were observed. Results There was no difference in rat weight between the groups.The values of PaO2and PaO2/FiO2were increased.The lung index and wet/dry ratio,IL-1,TNF-α,PCⅢ, TGF-β1 and IQA were all reduced. The lung histopathology damage was significantly lightened.as compared with the model group. Conclusion It has treatment effect of sulfotanshinone sodium in lung fibrosis in the ALI rats, which may be related with the adjustment on inflammatory factor.
