Expression and significance of BSAP(PAX-5)in anaplastic large cell lymphoma
10.3969/j.issn.1006-5725.2018.02.037
- VernacularTitle:B细胞特异性激活蛋白PAX-5在间变性大细胞淋巴瘤中的异常表达及意义
- Author:
Xuefeng LI
1
;
Meigang ZHU
;
Xiangdong DING
;
Xiaodong FENG
;
Zhikui ZHANG
;
Wei XU
Author Information
1. 广州金域医学检验中心病理科 广州510005
- Keywords:
anaplastic large cell lymphoma;
PAX-5
- From:
The Journal of Practical Medicine
2018;34(2):305-308
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of PAX-5 in anaplastic large cell lymphoma, discuss the value and pitfalls of PAX-5 in the diagnosis and differential diagnosis of lymphomas. Methods A total of 269 T lymphomas were studied retrospectively.PAX-5 positive anaplastic large cell lymphoma was confirmed by immo-munohistochemistry and gene rearrangement analysis. Literature review was performed and the clinicopathological features were discussed.Results Two cases of anaplastic large cell lymphoma were found with aberrant expression of PAX-5. Conclusions As a relatively specific B cell marker, PAX-5 can also express in anaplastic large cell lymphoma. In the diagnosis of lymphomas, especially the differential diagnosis between classical Hodgkin lympho-ma and Anaplastic large-cell lymphoma, diagnosis errors should be avoided by interpreting PAX-5 immunohisto-chemistry in the context of clinical features, morphology, a panel of B- and T-lineage-associated antibodies, and gene rearrangement analysis.
