Mac-2 binding protein glycosylation isomer compared with imaging examination in the prognosis of hepat-ic fibrosis in patients with hepatitis C
10.3969/j.issn.1006-5725.2018.02.034
- VernacularTitle:血清M2BPGi联合MRI-DWI预测丙型肝炎患者肝纤维化的临床价值
- Author:
Wei WANG
1
;
Yuping MA
;
Haiting MA
;
Xuan ZHOU
Author Information
1. 新疆医科大学附属中医医院影像中心 乌鲁木齐830000
- Keywords:
hepatic fibrosis;
M2BPGi;
ADC
- From:
The Journal of Practical Medicine
2018;34(2):293-296,300
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore and compare the prognostic ability of the serum level of M2BPGi and MRI imaging technology for hepatic fibrosis. Methods 118 patients who were diagnosed as hepatitis C were enrolled from March 2014 to March 2015 in our hospital.Their baseline data were recorded,and they were texted by imaging examination of MRI.Then all patients were followed-up 2 years.The patients were divided into hepatic fibrosis group and control group according to the follow-up results.Univariate analysis and Cox model were used to show that the prognostic factors influencing the prognosis of hepatic fibrosis in patients;meanwhile,the statistical significance factors were calculated by ROC curve.Results The serological markers of IV-C,HA and serum level of M2BPGi in hepatic fibrosis group were higher than those in control group,but its ADC values of liver was lower than those in control group,and the difference was statistically significant(P < 0.05). COX regression analysis showed that the difference of M2BPGi(RR = 4.282,P = 0.003)and ADC values(RR = 0.654,P = 0.004). The ROC analysis of the hepatic fibrosis group and the control group showed that the AUC of the combination was 0.865,the sensitivity and specificity were 95.2%,60.5%,respectively.Conclusion The clinical value the com-bined prognostic of them is of high prognostic efficacy,which is hopeful to be used as an auxiliary prognostic meth-od in clinic.
