Efficacy of etoposide capsule on metastatic breast cancer
10.3969/j.issn.1006-5725.2018.02.032
- VernacularTitle:依托泊苷胶囊治疗晚期转移性乳腺癌的疗效
- Author:
Huiai ZENG
1
;
Min YAN
;
Huimin LV
;
Men-Gwei ZHANG
;
Limin NIU
;
Zhenzhen LIU
;
Shude CUI
Author Information
1. 郑州大学附属肿瘤医院乳腺科 郑州450008
- Keywords:
etoposide capsule;
metastatic breast;
efficacy
- From:
The Journal of Practical Medicine
2018;34(2):285-288
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of etoposide capsule on metastatic breast cancer. Methods Forty-five advanced breast cancer patients treated with oral etoposide during Feb.1,2012 and Oct.31, 2016 in our department were enrolled in our study,with their general data,median number of treatment lines, treatment effect,common adverse reaction collected. Such indexes of objective response rate,rate of clinical benefit,disease control rate,progression free survival time were anlayzed. Results All patients received median five lines of etoposide capsule therapy. The objective response rate(ORR,CR + PR)was 6.7% and the clinical benefit rate(CBR,CR+PR+SD≥6.0 months)was 26.7% and the disease control rate(DCR,CR+PR+SD) was 68.9%.The median progression free survival time(PFS)was 4.0 months(95% CI:2.3~5.6).The main toxic-ities were grade 1-2 neutropenia(37.8%),grade 3-4 neutropenia(6.7%).Conclusion Etoposide capsule could be an option with efficacy and safety for metastatic breast cancer.
