The protective effect of dexmedetomidine atdifferent doses combined with ulinastatin in lung resection pa-tients with one lung ventilation
10.3969/j.issn.1006-5725.2018.02.031
- VernacularTitle:不同剂量右美托咪定联合乌司他丁对肺叶切除术患者肺损伤的保护作用
- Author:
Qiaoling ZHOU
1
;
Weicheng ZHAO
;
Meijuan LIAO
;
Hua LIANG
;
Han-Bin WANG
;
Hongzhen LIU
;
Chengxiang YANG
Author Information
1. 中山大学附属佛山医院麻醉科 广东佛山528000
- Keywords:
dexmedetomidine;
ulinastatin;
one lung ventilation;
lung injury
- From:
The Journal of Practical Medicine
2018;34(2):281-284
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the protective effect of dexmedetomidine(Dex)at different doses com-bined with ulinastatin in lung resection patients with one lung ventilation. Methods 80 patients having undergone unilateral lung resection were divided into four groups randomly:control group(C group)and groups Dex 1-3,20 cases in each group.One lung ventilation(OLV)was used in all the groups during operation.The patients in groups Dex 1-3 were treated with 0.5,1.0,2.0 μg/kg combined with ulinastatin,and the C group with amount of normal sa-line instead.The comparisons were done among the four groups in terms of SOD,L-6,IL-10,serum malondialde-hyde(MDA)concentration at 5 min after endotracheal intubation(T0),30 min(T1),60 min(T2),120 min (T3)as well as the levels of FVC,FEVl and FEVl/FVC at 24 h,48 h and 72 h after surgery. Results In the groups C and Dex 1,SOD decreased at T1-4 and IL-6,MDA and IL-10 at T2-4 rose.SOD decreased at T2-4 in groups Dex 2-3 and MDA,IL-6 and IL-10 rose.Compared with group C,the levels of SOD and IL-10 at T2-4 in groups Dex 1-2 and at T1-4 in group Dex 3 rose. In groups Dex 1-3,postoperative FVC,FEVl and FEVl/FVC rose.Compared with group Dex 1 or 2 respectively,SOD and IL-10 at T2-4 in group Dex 3 significantly rose,but MDA and IL-6 significantly declined;FVC,FEVl and FEVl/FVC significantly rose 48 h and 72 h after surgery (P<0.05). Conclusion Dex combined with ulinastatin has a protective effect for patients with one lung ventila-tion after lung resection,with the best-suggested dose of 1.0 μg/kg.
