Study on relationship between Th1/Th2 cells/cell cytokines and tuberculosis pleural effusion adhesion
10.3969/j.issn.1006-5725.2018.02.020
- VernacularTitle:Th1/Th2细胞及细胞因子和结核性胸膜炎粘连的相关性
- Author:
Ling LIU
1
;
Jingkui SHU
;
Jianghai WU
;
Jiagang FENG
;
Huirong CHEN
Author Information
1. 昆明医科大学第一附属医院呼吸内二科 昆明650032
- Keywords:
tuberculosis pleurisy;
internal thoracoscope;
pleural adhesion;
T-helper lymphocyte;
cyto-kines
- From:
The Journal of Practical Medicine
2018;34(2):239-242,246
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between cellular immune response which is related with Th1/Th2 cells and the different severities of tuberculosis pleural effusion adhesion.Methods A total of 66 in-patients diagnosed with different severities of tuberculosis pleural effusion adhesion by internal thoracoscope were enrolled from August 2014 to December 2016.ELISA was used to determine levels of INF-γ,TNF-α,IL-2 and IL-4. The ratio of Th1 and Th2 cells was detected by flow cytometry. Results All the patients were divided into 3 groups:9 cases without pleural adhesion,32 cases with mild pleural adhesion,25 cases with severe pleural adhe-sion. The levels of 4 cytokines in pleural fluid were significantly higher than those in serum in each group(P <0.05,respectively).The concentrations of INF-γ and TNF-α were increased with the severity of tuberculosis pleu-ral effusion adhesion. The levels of INF-γ and TNF-α in the severe pleural adhesion group were markedly higher than those in the other two groups(P<0.05,respectively).The proportion of Th1 cells in the severe pleural adhe-sion group was significantly higher than that in the none pleural adhesion group and in the mild pleural adhesion group(P<0.05,respectively).Conclusions The proportion of Th1 cells and levels of INF-γ and TNF-α are pos-itively related with pleural adhesion severity. Cellular immune response which is related with Th1 cells contributes to pathological immune pleural damage and intensify the severity of pleural adhesions.