A case-control study on the relationship between serum FGF-21 and coronary heart disease
10.3969/j.issn.1006-5725.2018.02.009
- VernacularTitle:血清成纤维细胞生长因子21水平与冠心病的病例对照研究
- Author:
Wenhui LIU
1
;
Yun LIU
;
Zhe ZHANG
;
Jianxin HE
;
Yuan ZHANG
;
Jian QIU
Author Information
1. 南方医科大学研究生 广州510515
- Keywords:
coronary heart disease;
fibroblast growth factor 21;
case-control study
- From:
The Journal of Practical Medicine
2018;34(2):199-201
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of serum fibroblast growth factor 21(FGF-21)with coronary heart disease(CHD)and biochemical indexes. Methods Serum FGF-21 expression was detected by ELISA.310 healthy control subjects and 310 CHD patients were recruited.Basic information was obtained by clini-cal questionnaires. Venous blood was tested for serum lipid,fasting glucose,and C-reactive protein(CRP). All the data were analyzed with the SPSS 19.0. Results There were no significant differences in gender and age be-tween CHD and controls(P > 0.05). FGF-21 level was significantly higher in CHD patients than in the controls (P<0.05).Univariate analysis showed serum FGF-21 was a risk factor of CHD.The group of higher score for FGF-21 had a 5.20-fold risk of CHD than the group of lower score without adjustment for confounding factors(95% CI:4.23~8.42).After control of the confounding factors,the group of higher score had a 7.21-fold risk of CHD(95% CI:3.78~13.67)than the group of lower score,it remains the significant difference(P<0.05).Conclusion Ele-vation of serum FGF-21 was closely associated with initiation and development of CHD.
