Study on correlation between 25-hydroxyvitamin D level and seasons among 13 502 children in Guangzhou area
10.3969/j.issn.1006-5725.2018.01.035
- VernacularTitle:广州地区13502例儿童25-羟基维生素D水平及其与季节关系
- Author:
Lan LIN
1
;
Meizhen TAN
;
Yulian XIAO
;
Yanping YANG
;
Li CHEN
;
Chunling ZHANG
Author Information
1. 广州市妇女儿童医疗中心保健科
- Keywords:
25-hydroxyvitamin D;
children;
vitamin D deficiency;
hypervitaminosis D;
vitamin D toxicity;
changes of season
- From:
The Journal of Practical Medicine
2018;34(1):140-143
- CountryChina
- Language:Chinese
-
Abstract:
Objective The age and seasonal variation in children's serum 25-hydroxyvitamin D (25(OH) D] were analyzed retrospective and to provide some guides on clinical application.Methods The serum 25(OH) D level was detected by using enzyme-linked immunosorbent assay kit in 13 502 children that took health examination in Guangzhou Women and Children's Medical Center in February,march,September and October from 2009 to 2011.The cases were divided into five age groups.The average levels,deficiency and overdose of vitamin D (VD),were analyzed.Results The average 25(OH)D in serum was (80.81±42.39) nmol/L in 13 502 cases,(72.71 ± 33.47) nmol/L in Feb.and Mar.group,(89.91 ± 49.01) nmol/L in Sep.and Oct.group.There was statistically significant difference on serum 25 (OH)D level between seasons and between boys and girls for 6 years older groups.The serum 25 (OH) D levels significantly decreased with increasing age.There were statistically significant differences in serum 25 (OH) D levels and between the VD deficiency and the lack of number of cases in the 5 age groups of the two seasons.The number of VD deficiency was 482 cases (3.57％) whose 25 (OH) D ＜ 37.5 nmol/L,and 1850 cases (13.7％) whose 25 (OH) D ＜ 50.0 nmol/L.The VD deficiency in each age group was 8.19％,13.97％,37.72％,52.63％,57.92％ in Spring,and 2.38％,4.15％,10.36％,16.85％,27.47％ in Summer.The number of lack of VD was in 6 973 cases (51.64％);Excessive and poisoning of VD were 34 cases (0.25％) and 35 cases (0.26％).Conclusions Children had a relatively low level of VD in Guangzhou area,especially in the spring and school-age children with more severe VD deficiency.It is necessary to supplyVD timely in accordance with the age and season,and children were encouraged to spend more time outdoors.
