Clinical analysis of 34 cases with diffuse alveolar hemorrhage in systemic lupus erythematosus
10.3969/j.issn.1006-5725.2018.01.025
- VernacularTitle:系统性红斑狼疮合并弥漫性肺泡出血34例临床分析
- Author:
Zichen HUANG
1
;
Hejun WANG
;
Cheng ZHAO
;
Leting ZHENG
;
Jing WEN
;
Zhanrui CHEN
;
Ling LEI
Author Information
1. 广西医科大学第一附属医院风湿免疫科
- Keywords:
systemic lupus erythematosus;
diffuse alveolar hemorrhage
- From:
The Journal of Practical Medicine
2018;34(1):100-102,106
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify the clinical characteristics and therapeutic effect of systemic lupus erythematosus (SLE) patients with diffuse alveolar hemorrhage (DAH).Methods Clinical characteristcs,diagnosis,treatment and outcome in 34 patients hospitalized in The First Affiliated Hospital of Guangxi Medical University from January 2006 to December 2016 were retrospectively analyzed.Results The incidence of DAH involvement of SLE was about 0.39％.Median age was 19 (interquartile range (IQR) 11.75 ～ 32) years.The duration of SLE before clinical DAH was 6 months (IQR 2 ～ 15.75) months.The main clinical manifestations of DAH were cough,dyspnea and fever.The SLE disease activity index (SLEDAI) score was 19.5 (16 ～ 25)points and anti-dsDNA antibody titer elevated markedly (38.2％).The overall mortality rate was 73.5％,however patients who chose department of rheumatism have lower mortality (52.9％).And treatment of CTX was associated with mortality (OR =0.059,95％ CI 0.006 ～ 0.554,P =0.013),as well as steroids and immunosuppressant combination therapy.Conclusions The clinical symptoms of SLE with DAH is often atypical.There is manifestation of cough,fever,dyspnea and etc.Imaging and broncoscopy can assist the diagnosis and its prone to the pulmonary infection and high mortality.Early diagnosis and application of CTX combined with conventional dose of hormone theraphy can in early diagnosis and reduce the mortality.
