The effect of targeting interleukin-6 receptor on leukocyte production after acute myocardial infarction
10.3969/j.issn.1006-5725.2018.01.009
- VernacularTitle:靶向抑制白细胞介素6受体对急性心梗后白细胞产生的影响
- Author:
Chunbian CUI
1
;
Xinwei JIA
;
Yanfei WANG
;
Ya LI
;
Zhanqi WANG
;
Jing WANG
Author Information
1. 河北大学附属医院,河北保定071000
- Keywords:
myocardial infarction;
interleukin;
interleukin-6 receptor;
hematopoiesis;
cardiocytes remodeling
- From:
The Journal of Practical Medicine
2018;34(1):34-38
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of Tocilizumab on white blood cell (WBC) after acute myocardial infarction (MI) and explore its potential to treat MI.Methods Rats were divided into 3 groups:control,MI,and MI treated.Serum from individual mouse was collected before and after subcutaneously Tocilizumab treatment.The level of interleukin-6 (IL-6),the number of WBC and the ratio of active hematopoietic stem cell (HSC)was tested by ELISA,flow cytometry and blood routine examination.The fibrosis of heart tissue was observed by immunohistochemistry.Results The IL-6 level and the number of the WBC were reduced after Tocilizumab treatment.It indicates the effect of inhibiting the activity of HSC and improving the situation of cardiocytes remodeling.Conclusion Tocilizumab could inhibit the generation of WBC and re-construct myocardium after MI.
