Diagnostic value of CEA, CA153, TPS, Fer and CYFRA21-1 in postoperative metastasis of breast cancer
10.3969/j.issn.1006-5725.2017.22.034
- VernacularTitle:CEA、CA153、TPS、Fer、CYFRA21-1检测在乳腺癌术后转移中的诊断价值
- Author:
Yuzhu LI
1
;
Yumin ZHANG
;
Longcai HAN
;
Hua ZHANG
;
Xintang LIU
;
Haijun ZHANG
;
Qiuquan LIN
;
Lei WANG
Author Information
1. 063000,河北省唐山市人民医院放射科
- Keywords:
breast cancer;
metastasis;
CEA;
CA153;
TPS;
Fer;
CYFRA21-1
- From:
The Journal of Practical Medicine
2017;33(22):3810-3814
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the diagnostic value of tumor markers of CEA,CA153,TPS,Fer and CYFRA21-1 level in postoperative metastasis of breast cancer.Methods After 3-year follow-up for 578 patients with primary breast cancer from 2012 to 2014,we chose 42 patients with metastasis as metastasis group,and another 42 cases without as non-metastasis group.Level of CEA,CA153,TPS,Fer and CYFRA21-1 was detected using chemiluminescence and the difference of CEA,CA153,TPS,Fer and CYFRA21-1 level in 2 groups was compared.Pearson correlation test analysis and ROC curve test were performed for data analysis.Results Serum CEA,CA153,TPS,Fer and CYFRA21-1 levelq6.11 ± 1.87)ng/mL,(26.97 ± 9.52) U/mL,(155.95 ± 22.03)U/L,(173.08 ± 19.87)ng/mL and (18.98 ± 7.33)ng/mL respectively increased in metastasis group when compared with those in non-metastasis group (5.33 ± 1.85)ng/mL,(23.34 ± 8.30)U/mL、(133.22 ± 19.09)U/L,(142.29 ± 22.59) ng/mL and (6.76 ± 1.59)ng/mLrespectively and the change of TPS,Fer and CYFRA21-1 was more obvious and the difference was statistically significant (P ＜ 0.05).There was no significant correlation among serum TPS,Fer and CYFRA21-lin metastasis group.The area under ROC curve of CYFRA21-1 was 0.903,followed by Fer (0.849) and TPS (0.791) and in the diagnosis of metastasis of breast cancer,CYFRA21-1 has great diagnostic value.Conclusions The increase of serum TPS,Fer and CYFRA21-1 level is closely associated with postoperative metastasis of breast cancer and CYFRA21-1 has great diagnostic value for monitoring postoperative metastasis of breast cancer.
