Role of astograph methacholine provocation test in diagnosis of bronchial asthma
10.3969/j.issn.1006-5725.2017.22.033
- VernacularTitle:Astograph法支气管激发试验在诊断哮喘的作用研究
- Author:
Hongkuan YANG
1
;
Jiaying ZHANG
;
Fang WANG
;
Fang CHEN
Author Information
1. 浙江中医药大学第一临床医学院
- Keywords:
bronchial asthma;
astograph;
methacholine provocation test;
airway hyper-responsiveness;
diagnosis
- From:
The Journal of Practical Medicine
2017;33(22):3807-3809
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the diagnostic value of astograph methacholine provocation test for bronchial asthma.Methods A total of 238 asthma patients and 499 non-asthma patients participated in the detection by astograph methacholine provocation test.Statistical methods were used to analyze the differences of astograph parameters and find the indicators of asthma diagnosis and the critical value.Results Dmin,Cmin and PD15 were much lower in the asthma group (P ＜ 0.01),compared with the the non-asthma group,when SGrs,SGrs/Grs cont were much higher (P ＜ 0.01).SGrs was relevant with Dmin,Cmin,PD15 in the asthma group (P =0.000;r =0.685,r =0.657,r =0.639) as well as the SGrs/Grs cont did (P =0.000,r =0.775;r =0.740,r =0.708).In ROC analysis,Dmin presented an AUC of 0.661,the cutoff value was 2.71 unit,with a sensitivity of 0.739 and specificity of 0.551.PD15 presented an AUC of 0.746,the cutoff value was 4.856 5 unit,with a sensitivity of 0.693 and specificity of 0.684.Conclusion Astograph methacholine provocation test shows good sensitivity and specificity in the diagnosis of asthma,particularly when Dmin ≤ 2.71 Unit or PD15 ≤ 4.8565 Unit as the cutoff value.
