The distributions and clinical characteristics of pathogenic bacteria in severe acute pancreatitis patients with the secondary infection
10.3969/j.issn.1006-5725.2017.22.024
- VernacularTitle:重症急性胰腺炎继发感染的病原菌分布及临床特点分析
- Author:
Yao WANG
1
;
Youjian ZHANG
;
Meilin YE
;
Min WANG
;
Xia CHEN
;
Yan PENG
Author Information
1. 西南医科大学附属医院消化内科
- Keywords:
severe acute pancreatitis;
infection;
pathogenic bacteria;
drug resistance
- From:
The Journal of Practical Medicine
2017;33(22):3773-3776
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the distributions and clinical characteristics of pathogenic bacteria in SAP patients with secondary infection.Methods We collected clinical data from SAP patients with secondary infection,to analyze the source of samples,pathogenic bacteria and its resistance to commonly used antimicrobial agents.Results (1) Samples Source:A total of 156 positive specimens were obtained,with the largest number from sputum samples (46.79％);The blood samples (70.59％) were collected most within 1 week,sputum samples (64.38％) from 1 week to 2 weeks,and pancreatic necrotic tissues or peripancreatic fluid samples (51.79％) after 3 weeks,with statistically significant differnces.(2) Pathogenic bacteria:156 strains were isolated including 86 strains (55.13％) of gram-negative bacteria (55.13％),of which acinetobacter baumannii and escherichia coli were the most commonly seen,followed by gram-positive bacteria of 41 strains (26.28％),and then fungus of 27 strains (18.59％).(3) Drug resistance:There was a high tolerance rate of commonly used antimicrobial agents,and the drug resistance rate of cinetobacter baumannii to carbapenems antibiotics was 88.00％.Conclusions SAP combined with secondary infection is mainly caused by gram-negative bacteria,and there is a high proportion of multidrug-resistant bacteria.Selecting suitable antimicrobial agents according to bacterial culture is beneficial for the early control of infections.
