Effect of prescription medication on circadian rhythm of blood pressure in non-dipper hypertensive patients
10.3969/j.issn.1006-5725.2017.22.015
- VernacularTitle:择时用药对非杓型高血压患者血压昼夜节律的影响
- Author:
Zhongxiao ZHANG
1
;
Chun YANG
;
Guowen YANG
;
Yali LU
Author Information
1. 400053,重庆市第十三人民医院心内科
- Keywords:
non-dipper type hypertension;
Telmisartan;
blood pressure circadian rhythm;
matrix metalloproteinase 9;
Chemerin protein
- From:
The Journal of Practical Medicine
2017;33(22):3737-3741
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of combined prescription medication on non-dipper hyperten sive patients.Methods 76 patients with non-dipper hypertensive patients were randomly divided into group A (n =38) and group B (n =38).Telmisartan tablets,hydrochlorothiazide tablets and levamlodipine tablets were given in two groups.Patients in group A take oral medicine at 8 pm,and patients in group B take oral medicine at 8 pm.The levels of plasma angiotensin Ⅱ,plasma endothelin-1 (ET-1),plasma renin,matrix metalloproteinase9 (MMP-9) and Chemerin protein were observed in both groups.Results After treatment,24 h SBP,dSBP and nSBP in group B were significantly lower than those in group A (P ＜ 0.05).The dipper value of group B was significantly higher than that of group A (P ＜ 0.05).The diversion rate of group B was significantly higher than that of group A (P ＜ 0.01).The levels of renin,angiotensin Ⅱ,ET-1,MMP-9 and Chemerin in group B were significantly lower than those in group A at 6 AM and 0:00 (P ＜ 0.05).The degree of change in group B at 0:00 was more significant than that in 6:00 AM (P ＜ 0.05).There was no significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05).Conclusion The efficacy of telmisartan,hydrochlorothiazide combined with levamlodipine in patients with non-dipper hypertensive patients performs better if patients take medicine at 8 pm other than at 8 pm.
