Expression and clinical significance of plasma long non-coding RNA MALAT1 in patients with oral squamous cell carcinoma
10.3969/j.issn.1001-3733.2018.02.009
- VernacularTitle:长链非编码RNA MALAT1在口腔鳞状细胞癌患者血浆中的表达及意义
- Author:
Jun WANG
1
;
Siyu ZHAO
;
Shaobo OUYANG
;
Lan LIAO
Author Information
1. 南昌大学第二附属医院口腔颌面外科
- Keywords:
Oral Squamous Cell Carcinoma(OSCC);
Long non-coding RNA(lncRNA);
Metastasis-associated lung adenocarcinoma transcript 1(MALAT1);
Biomarker
- From:
Journal of Practical Stomatology
2018;34(2):188-192
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the expression of long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in plasma of patients with oral squamous cell carcinoma (OSCC) and its clinical significance. Methods: 70 OSCC patients and 50 healthy controls were included. The relative expression of MALAT1 in plasma was examined by quantitative realtime PCR. The expression of MALAT1 in plasma in 15 OSCC patients was analyzed retrospectively 30 days after operation. Results: The expression level of MALAT1 in plasma of OSCC patients was significantly higher than that of healthy controls(P＜ 0. 001). The expression level of MALAT1 in OSCC patients was significantly correlated with TNM stage, tumor differentiation and lymph node metastasis(P＜ 0. 05). After operation the expression level of MALAT1 in plasma of OSCC patients was significantly decreased(P＜ 0. 001). The AUC of the diagnosis of OSCC with MALAT1 was 0. 814, and the sensitivity and specificity were 87. 43％ and 72. 00％ respectively. Conclusion: MALAT1 can be used as an auxiliary diagnostic marker for OSCC.
