Construction and characterization of an antibacterial peptide controlled release coating for percutaneous implant

VernacularTitle:一种经皮种植体抗菌肽控释涂层的构建及性能研究
Author: Qiang MIAO ¹ ; Yuning XIA ; Meng MENG ; Zhengyu ZHANG ; Chufan MA
Author Information

1. 710032 西安,军事口腔医学国家重点实验室,口腔疾病国家临床医学研究中心,陕西省口腔医学重点实验室,第四军医大学口腔医院修复科
Keywords: TiO2 nanotube; Antimicrobial coating; Sustained-release; Antibiotic peptide
From: Journal of Practical Stomatology 2018;34(2):149-152
CountryChina
Language:Chinese
Abstract: Objective: To construct an antibacterial peptide controlled release coating for percutaneous implant and to study its release and antibacterial properties. Methods: TiO2 nanotube specimens were prepared by anodizing. PDLLA was used as the retarder and HHC-36 as the antibacterial peptide, PDLLA-HHC-36 were loaded on TiO2 nanotube surface by solvent-casting technology. The surface form of the specimens was observed under SEM. Sustained release was analyzed by the release curves and the antibacterial effect was examined with inhibition zone test. Results: TiO2 nanotube specimens with 80-120 nm diameter were fabricated, the drug coating was observed under SEM. The drug loaded specimens showed 15 days sustained release in vitro and inhibition zone about 15 mm in diameter was found in the test for at least 10 days. Conclusion: TiO2 nanotube specimens with PDLLA-HHC-36 controlled release coating has sustained-release and antibacterial properties.