The effects of bone graft combined with enamel matrix derivative in the treatment of periodontal osseous defects compared with that of bone graft alone: A meta-analysis
10.3969/j.issn.1001-3733.2018.01.017
- VernacularTitle:釉基质蛋白衍生物联合植骨材料与单用植骨材料比较治疗牙周骨缺损疗效的Meta分析
- Author:
Wanlu GUO
1
;
Deyu CHEN
;
Jinlong HE
;
Yurong WANG
Author Information
1. 重庆医科大学附属口腔医院·口腔疾病与生物医学重庆市重点实验室·重庆市高校市级口腔生物医学工程重点实验室
- Keywords:
Enamel matrix derivative;
Bone grafts;
Osseous defects;
Meta-analysis
- From:
Journal of Practical Stomatology
2018;34(1):77-83
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To analyze the efficacy of enamel matrix derivative (EMD) combined with bone grafts in the treatment of periodontal osseous defects comparied with that of bone grafts alone by Meta-analysis. Methods: The randomized controlled trials(RCTs) about the efficacy of enamel matrix derivative and bone grafts for the treatment of periodontal osseous defects were collected from Cochrane Library,EMBASE,PubMed,CNKI,Wanfang databases and Google scholar from inception may,2016 by electronic search,scored literatures with the methodological index for non-randomized studies(MINORS) evaluation tool. Revman 5. 3 was used for the Meta-analysis. Results: 5 RCTs articles with 145 cases were included. Meta-analysis showed that: at 6 months of follow-up, PD reduction and CAL gain was found more in test group than in control group(WMD = 0. 40,95％ CI =[0. 01,0. 79],P ＜ 0. 05) and (WMD = 0. 50,95％ CI =[0. 12,0. 88],P ＜ 0. 05) respectively. At 12 months of follow-up,there was no statistical significant difference in PD reduction and CAL gain respectively between the 2 treatments. Conclusion: The combined use of EMD and bone grafts may improve PD reduction and CAL gain in the early stage of convalescence following treatment of periodontal osseous deffects.
