The expression of bFGF in oral ulcer model of rabbits

VernacularTitle:bFGF在兔口腔溃疡模型中的表达
Author: Qi CHEN ¹ ; Cheng LUO ; Hong CHEN ; Song SU ; Wenguang FU ; Xin XIE ; Silin ZHENG
Author Information

1. 西南医科大学附属医院
Keywords: Rabbit; Oral ulcer; Basic fibroblast growth factor(bFGF)
From: Journal of Practical Stomatology 2018;34(1):43-46
CountryChina
Language:Chinese
Abstract: Objective: To detect the expression of basic fibroblast growth factor(bFGF) in oral mucosa with ulcer in rabbits. Methods: 72 New Zealand rabbits(with the weight of 3 000-3 500 g) were randomly divided into control group,model group,and treatment group(n = 24). 1,3,5 and 7 d after treatment buccal mucous membrane tissues of the rabbits were respectively taken from the 3 groups. The models of oral ulcer were examined by HE staining. The expression of bFGF mRNA was detected by RTPCR. The expression of bFGF protein was detected by immunohistochemistry. Results: The oral ulcer model of the rabbits was successfully established. Both RT-PCR and immunohistochemistry analyses showed that 1-7 d after treatment the expression levels of bFGF mRNA and protein were higher in treatment group than in model group(P ＜ 0. 05) and control group(P ＜ 0. 05),3-7 d after treatment were higher than in model group(P＞ 0. 05). Conclusion: bFGF may be a new therapeutic target for oral ulcer.