Association between CTLA-4 gene + 49A/G polymorphism and the risk of periodontitis: A Meta-analysis
10.3969/j.issn.1001-3733.2017.06.015
- VernacularTitle:CTLA-4基因+49A/G多态性与牙周炎发病风险的Meta分析
- Author:
Zheng ZHOU
1
;
Qi LI
;
Yun GAO
;
Xiaoxue TANG
;
Jiang XU
Author Information
1. 石河子大学医学院第一附属医院口腔科
- Keywords:
Cytotoxic T lymphocyte antigen 4 (CTLA-4);
Periodontitis;
+ 49A/G polymorphism;
Meta-analysis
- From:
Journal of Practical Stomatology
2017;33(6):783-787
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the relationship between cytotoxic T lymphocyte antigen 4 (CTLA-4) gene + 49A/G polymorphism and the risk of periodontitis.Methods:A comprehensive literature research was electronically performed to retrieve currently published studies regarding the association of CTLA-4 gene +49A/G polymorphism with periodontitis susceptibility.The individual OR with 95％ CI was pooled to calculate the strength of the association using RevMan 5.2 software.Results:4 out of 18 seached studies satisfied the standard for Meta-analysis.A total of 702 cases and 926 controls were finally included in the Meta-analysis.Overall,no significant association of CTLA-4 gene + 49A/G polymorphism with the risk of periodontitis was observed (P ＞ 0.05).In the subgroup analysis by ethnicity,the results showed a significant association of CTLA-4 gene + 49A/G polymorphism with increased risk of periodontitis in Asian population(P ＜ 0.05) but not in Caucasian population(all P ＞ 0.05).The stratification analysis by subtypes of periodontitis revealed no significant association of the polymorphism with chronic and aggressive periodontitis respectively (all P ＞ 0.05).Conclusion:The present studies suggest that CTLA-4 gene + 49A/G polymorphism may be not associated with the risk of periodontitis in the overall population,but correlated with an increased risk of periodontitis in Asian population.
