Therapeutic efficacy of paclitaxel or paclitaxel liposome via arterial or venous perfusion in the treatment of rabbits tongue cancer
10.3969/j.issn.1001-3733.2017.06.001
- VernacularTitle:紫杉醇脂质体与紫杉醇不同途径灌注治疗兔舌癌的疗效研究
- Author:
Zenian LIU
1
,
2
;
Li YAO
;
Nini ZHANG
;
Guilin HUANG
;
Jie YI
;
Xiaohua HU
Author Information
1. 653003,遵义医学院附属口腔医院口腔颌面外科
2. 遵义高等医药专科学校
- Keywords:
Rabbit VX-2 tongue cancer;
Paclitaxel;
Paclitaxel liposome
- From:
Journal of Practical Stomatology
2017;33(6):719-722
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effects of the treatment for rabbit VX-2 tongue cancer with paclitaxel or paclitaxel liposome infusion through rabbit lingual artery or ear vein infusion.Methods:24 rabbits with VX-2 tongue cancer were divided into 6 groups(n =40) randomly.The rabits in 3 groups were respectively treated by intra-arterial infusion with paclitaxel,paclitaxel liposome and 5％ glucose,and those in other 3 groups by ear vein infusion with the same materials.After 7 days of treatment,the lesion volumes were measured for response evaluation,cells apotosis in the cancer tissure was detected by llowcytometry,P53 protein expression was examined by immunohistochemical staining,respectively.The data was analyzed by SPSS 20.0 software package.Results:The response rate and apotosis of the tumor cells in intra-arterial infusion with paclitaxel liposome group were higher than those in the other groups(P ＜ 0.05),P53 protein expression was lower than that of the other groups (P ＜ 0.05).Conclusion:Intra-arterial infusion through tongue artery with paclitaxel liposome is more effective than the other methods in the treatment of rabbit VX-2 tongue cancer.
