Effect of CT guided implantation of 125Ⅰ radioactive particles in superficial malignant tumors
10.3969/j.issn.1002-1671.2018.06.032
- VernacularTitle:CT引导下125Ⅰ放射性粒子植入治疗浅表恶性肿瘤
- Author:
Wei FU
1
;
Shixin CHEN
;
Zeng LI
;
Wu MA
;
Zhongqiu LIU
;
Zhigang FAN
;
Zhiyou ZHAO
;
Shan TIAN
Author Information
1. 西安交通大学医学院附属三二○一医院介入科
- Keywords:
superficial malignant tumor;
125Ⅰ radioactive particle;
computed tomography
- From:
Journal of Practical Radiology
2018;34(6):941-943
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the short-term clinical effect of CT guided 125Ⅰ radioactive particle therapy in superficial malignant tumor. Methods The clinic data of 28 patients with metastatic superficial malignant tumor in our hospital were analyzed retrospectively.All patients were treated with CT guided 125Ⅰ radioactive particle therapy.The short-term effects,1 year survival rate and 1 year progression free survival rate of the patients were compared.Results Objective remission rate(ORR)and disease control rate(DCR)after 6 months were 92.86% and 100.00%.1 year overall survival and 1 year progression free survival were 96.43%(27/28)and 82.14%(23/28), respectively.The median overall survival and median progression free survival were 26.978 months (95%CI:22.558-31.399)and 16.932 months (95 % CI:14 .471-19.393).There were 27 cases of 0-Ⅱ degree adverse reactions,1 case of grade Ⅲ adverse reactions and no grade Ⅳ adverse reactions.No signs of 125Ⅰ radioactive particle translocation,vascular embolism and vascular rupture were found. Conclusion 125Ⅰ radioactive particle treatment of superficial malignant tumor has a definite short-term curative effect,with overall survival and progression free survival longer and higher safety,which can be considered in clinical application.
