Quantitative assessment of myocardial microcirculation damage in patients with end-stage renal disease by CMR
10.3969/j.issn.1002-1671.2018.06.015
- VernacularTitle:终末期肾病心肌微循环异常的CMR量化评价
- Author:
Rong XU
1
;
Yingkun GUO
;
Zhigang YANG
;
Xi WU
;
Zhenlin LI
;
Chunchao XIA
;
Huayan XU
;
Wanlin PENG
;
Yi ZHANG
Author Information
1. 四川大学华西第二医院放射科
- Keywords:
microcirculation dysfunction;
end-stage renal disease;
cardiac magnetic resonance
- From:
Journal of Practical Radiology
2018;34(6):873-877
- CountryChina
- Language:Chinese
-
Abstract:
Objective To quantitative evaluate the myocardial microcirculation dysfunction in patients with end-stage renal disease (ESRD),and to provide the imaging characteristic for early detection myocardial dysfunction and microcirculation damage in the ESRD patients after dialysis therapy.Methods Sixty-seven patients with ESRD and 1 9 healthy subj ects were enrolled in our study, and the ESRD patients were divided into two groups including patients with preserved systolic function (n=51,EF≥50%)and patients with impaired systolic function (n=16,EF＜50%).The LV regional myocardial perfusion parameters were analyzed including upslope, time to maximum signal intensity (TTM)and max signal intensity (Max SI).Those continuous variables were compared using one-way analysis of variance (A N OVA )in all three groups.Results Compared with the controls and the ESRD patients with preserved EF,the ESRD patients with impaired EF had a significantly lower SV and markedly increased LV mass (all P＜0.001).For the fist-pass perfusion analysis,first-pass perfusion Max SI of all segments were significantly reduced in the ESRD patients with preserved/impaired EF compared with the normal subjects (all P＜0.05).Compared with the ESRD patients with preserved EF and controls,the ESRD patients with impaired EF had lower upslope in the basal segment (P＜0.05).And the ESRD patients with preserved/impaired EF had shorter TTM in the apical segment than that in normal controls (P＜0.01).Conclusion The CMR first-pass perfusion can detect the myocardial deformation and dysfunction in ESRD patients,the Max SI may be more valuable to early detect myocardial microcirculation dysfunction.
