Resting-state functional magnetic resonance imaging study in type 2 diabetic retinopathy using regional homogeneity analysis
10.3969/j.issn.1002-1671.2018.06.004
- VernacularTitle:利用ReHo方法的2型糖尿病视网膜病变rs-fMRI研究
- Author:
Xiaomin GE
1
;
Yi LU
;
Ling ZOU
;
Wei LIU
;
Changjie PAN
;
Hanqi CHEN
;
Hao ZHANG
;
Zhongling WANG
Author Information
1. 南京医科大学附属常州市第二人民医院放射科
- Keywords:
resting-state functional magnetic resonance imaging;
regional homogeneity;
type 2 diabetic retinopathy
- From:
Journal of Practical Radiology
2018;34(6):831-834
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the altered spontaneous cerebral activity in patients with type 2 diabetic retinopathy (T2DR). Methods Twenty-one patients with T2DR and sixteen healthy control subject underwent rs-fMRI scans,and the data were analyzed statistically using regional homogeneity(ReHo)method to observe the change of ReHo value.Results Compared to the control group,the T2DR group showed significantly increased ReHo value in the right occipital gyrus,occipital gyrus,inferior occipital gyrus and lingual gyrus regions (t=5.30,P＜0.05,voxel＞30,AlphaSim corrected),and significantly decreased ReHo value in the left posterior cingulate,margin lobe,right inferior parietal lobule,superior temporal gyrus and hippocampus (t=-4.01,-4.86,P＜0.05,voxel＞30, AlphaSim corrected).Conclusion The patients with T2DR showed significantly increased ReHo values in the brain visual cortex and visual pathway that were associated with the injury of brain function regions.It is of important value to evaluate brain dysfunction in patients with T2DR using ReHo method of rs-fMRI.
