The value of 3D-ASL parameters for predicting glioma grade before operation and the relationship between the expression of Ki-67 and MVD
10.3969/j.issn.1002-1671.2018.05.002
- VernacularTitle:3D-ASL参数对胶质瘤术前分级的价值及与Ki-67、MVD表达间关系的对照研究
- Author:
Jing WU
1
;
Wensheng WANG
;
Songtao LI
;
Zechun HUANG
;
Lili ZHONG
;
Hanbo LIN
;
Wenjian HUANG
;
Peng HE
Author Information
1. 广东三九脑科医院影像中心
- Keywords:
glioma;
arterial spin labeling;
magnetic resonance imaging;
Ki-67;
microvessel density
- From:
Journal of Practical Radiology
2018;34(5):654-657,665
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of 3D-ASL parameters for predicting glioma grade before operation and the relationship between the expression of Ki-67 and microvessel density(MVD).Methods 3DASL images of 50 patients with pathologically proven gliomas (high grade:n=20,1ow grade:n 30) were analyzed retrospectively.The mean maximum relative cerebral blood flow was obtained by the hot spot method.The Ki-67 labeling index and MVD of surgical specimen were measured.The results were analyzed statistically.Results The mean rCBF,Ki-67 and MVD of low grade gliomas (n=30) were 1.69±1.27,3.73％±3.01％,25.43±13.03,while the high grade gliomas (n=20) were 3.18± 1.46,49.25％ ±20.15％,58.69±20.39 respectively.The difference between the two groups was statistically significant (P＜0.01),which was positively correlated with the grade(r=0.620,0.871,0.698,P＜0.01).rCBF was positively correlated with Ki-67 and MVD (r =0.535,0.723,P ＜0.01).Ki 67 labeling index was positively correlated with MVD (r=0.629,P＜0.01).Conclusion The rCBF value is useful for predicting glioma grade before operation and related to tumor MVD and cell proliferation.The biologic behavior of glioma can be predicted to a certain extent.
