Longitudinal MRS study of the corpus callosum in patients with diffuse axonal inj ury
10.3969/j.issn.1002-1671.2018.04.004
- VernacularTitle:弥漫性轴索损伤患者胼胝体MRS纵向评估
- Author:
Dacong ZHAO
1
;
Guanghua LU
;
Jiang GUO
;
Xiaoyu SUN
;
Hui YU
Author Information
1. 达州市中西医结合医院 MRI室
- Keywords:
diffuse axonal injury;
corpus callosum;
magnetic resonance spectrum
- From:
Journal of Practical Radiology
2018;34(4):505-508
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate metabolic levels of the splenium and genu of corpus callosum(CC)in subacute diffuse axonal injury (DAI)patients,and their longitudinal change in a short time.Methods 12 patients with subacute DAI and 12 gender and age matched healthy controls were enrolled successively in this study.All subjects were scanned with single volume magnetic resonance spectrum(MRS)in two regions of interest(the splenium and genu of CC),and they were reexamined with MRS a month later(31.5 d±6.2 d, 28-43 d).Some metabolite concentrations were calculated quantitatively by using LC-model software and the differences were analyzed.Results The concentrations of NAA in the splenium and genu of CC in subacute DAI patients were decreased significantly compared with those of controls (the genu:t=4.474,P=0.001;the splenium:t=4.231,P=0.001),meanwhile the Cho concentrations were increased significantly (the genu:t=2.509,P=0.031;the splenium:t=2.195,P=0.018).The concentrations of NAA and Cho in the splenium and genu of CC in patients with the follow-up were slightly elevated when compared with those of subacute DAI patients,but the difference had no statistical significance.The concentrations of Cr in the splenium and genu of CC in all subjects had no statistic difference.Conclusion The single volume MRS is sensitive to reflect the metabolic levels of CC in subacute DAI patients.The metabolic levels of CC has no significant change in the short term (about 1 month).
