The evaluation of the tumor diameter combined ADC values for the therapeutic efficacy of neoadj uvant chemotherapy in each subtype of breast cancer
10.3969/j.issn.1002-1671.2018.03.010
- VernacularTitle:肿瘤直径联合ADC值对不同亚型乳腺癌NAC疗效的评估价值
- Author:
Dandan ZHANG
1
;
Zhiguo ZHUANG
;
Xiaochuan GENG
;
Lan LI
;
Jia HUA
Author Information
1. 上海交通大学医学院附属仁济医院(东院)放射科
- Keywords:
breast cancer;
neoadjuvant chemotherapy;
tumor diameter;
apparent diffusion coefficient
- From:
Journal of Practical Radiology
2018;34(3):366-369,385
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the values of change of diameter (ΔD%)on DCE-MRI and ΔD% combined with ADC for the therapeutic effect evaluation in the neoadjuvant chemotherapy(NAC)of each subtype of breast cancer.Methods 121 women with invasive breast cancer were enrolled in this study,including 56 cases of Luminal A type,42 cases of Luminal B type,13 cases of Her-2 type and 10 cases of triple negative type.Results Imaging evaluation results obtained by single applying DCE-MRI was analyzed with the pathological results after surgery for the consistency,and the Kappa values of Luminal A,Luminal B,Her-2 and triple negative type were 0.594,0.617,0.401,0.690,0.800,respectively.When combining ΔD% with ΔADC%,the Kappa values were 0.844,0.792,0.854, 0.847 and 0.800,respectively.The sensitivity of combined parameters in evaluating pCR after NAC was significantly increased in Luminal type cancers,however,with a slightly increasing in Her-2 type,and constant in triple negative type.Conclusion ΔD% combining with ΔADC% is better than single parameter in evaluating pCR for Luminal and Her-2 types cancer,but not for triple negative type.
