The fMRI study of brain inhibitory control function difference between DRD2 gene subtype of heroin addicts
10.3969/j.issn.1002-1671.2018.03.001
- VernacularTitle:不同DRD2基因型的海洛因成瘾者抑制性控制功能的fMRI研究
- Author:
Xiaohuai LI
1
;
Yarong WANG
;
Wei LI
;
Qiang LI
;
Yongbin LI
;
Jiajie CHEN
;
Jianjun YE
;
Dongsheng ZHANG
;
Wei WANG
Author Information
1. 空军军医大学唐都医院放射科
- Keywords:
DRD2 genes;
inhibitory control;
magnetic resonance imaging
- From:
Journal of Practical Radiology
2018;34(3):329-333
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the difference in inhibitory control ability between DRD2 gene subtype of heroin addicts with fMRI.Methods Thirty-seven heroin-dependent patients were divided into DRD2 Taq IA+ group (A+,22)and matched DRD2 Taq IA-group (A-,15).Functional MRI was performed in all patients while they were executing an event-related go/nogo task at 3.0T MR scanner.The differences of brain activated images and behavioral data between the two groups were analyzed with SPM8 and SPSS1 6.0 software,respectively.Results There were no significant differences in reaction time,accuracy and false alarm rates between the two groups (P>0.05).Compared with A-group,weaker activation in the medial prefrontal cortex,dorsal anterior cingulate,middle cingulate,supplementary motor area,temporal lobe,fusiform gyrus,lingual gyrus,hippocampus and parahippocampal gyrus in response inhibition condition were demonstrated in A+ group (voxel number>228,t=2.11,Alphasim correction,P<0.05).There was no corrlation between the intensity within the activated brain regions and the usage of heroin,morphine urine test positive number(P>0.05).Conclusion DRD2 Taq IA+ group exist deactivation of the brain area on memory,inhibitory control,visual spatial attention. It may be the neural basis that contribute to easy addiction and relapse for A+ carriers.
