Effects of alprostadil on oxidative stress in contrast-induced nephropathy in patients with chronic kidney disease
10.3969/j.issn.1002-1671.2018.02.029
- VernacularTitle:前列地尔对慢性肾病患者对比剂肾病的抗氧化应激作用
- Author:
Baiqiang MEI
1
;
Xili YANG
;
Zhaoyan XU
;
Jinming CEN
;
Zhaolun ZHOU
;
Jianmin LI
;
Jian LI
;
Jieyuan LI
;
Caiqin HE
;
Shaomei TANG
Author Information
1. 中山大学附属佛山市第一人民医院心内科
- Keywords:
alprostadil;
chronic kidney disease;
contrast-induced nephropathy;
oxidative stress
- From:
Journal of Practical Radiology
2018;34(2):274-277
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the anti-oxidative effects of alprostadil on contrast-induced nephropathy(CIN)after percuteous coronary intervention (PCI)in patients with chronic kidney disease(CKD).Methods A total of 200 patients with CKD were enrolled in our hospital.According to the random number table was divided into alprostadil 100 cases,100 cases of conventional treatment group.The levels of serum creatinine (Scr),creatinine clearance (eGFR),serum cystatin C (ScysC)and 8-hydroxy-deoxyguanine (8-OHdG)were observed before and after operation at 72 h and 7 d after operation.Results The incidence of CIN in the alprostadil group was significantly lower than that in the conventional treatment group (6% vs 12%,P<0.05).There was no significant difference in the level of Scr,eGFR,ScysC and 8-OHdG between the alprostadil group and the conventional treatment group (P>0.05).The level of Scr in the alprostadil group was significantly lower than that in the conventional treatment group at 72 h and 7 d after operation.The level of eGFR was significantly higher than that of the conventional treatment group (P<0.05).The levels of ScysC and 8-OHdG in the two groups were significantly higher than those before operation at 72 h and 7 d(P>0.05).The levels of ScysC and 8-OHdG in the alprostadil group were significantly lower than those in the conventional treatment group at 72 h and 7 d after PCI(P<0.05).Conclusion Alprostadil may improve the oxidative stress in patients with CKD and provide a preventive effect on CIN.
