The value of 3D-DIXON in quantitative diagnosis of non-alcoholic fatty liver disease
10.3969/j.issn.1002-1671.2017.11.011
- VernacularTitle:3D-DIXON定量诊断非酒精性脂肪肝的价值
- Author:
Min ZHANG
1
;
Min WANG
;
Shouqiang JIA
;
Shuncheng HE
Author Information
1. 泰山医学院附属莱芜医院影像科
- Keywords:
non-alcoholic fatty liver disease;
3D-DIXON;
IN/OPP;
proton magnetic resonance spectroscopy;
hepatic fat fraction value
- From:
Journal of Practical Radiology
2017;33(11):1692-1695
- CountryChina
- Language:Chinese
-
Abstract:
Objective To access the value of three dimensional gradient echo two-point Dixon water-fat separation sequence (3 D-DIXON) in quantitative diagnosis of non-alcoholic fatty liver disease(NAFLD) by comparing with in-phase/opposed-phase (IN/OPP)and proton magnetic resonance spectroscopy (1 H-MRS).Methods A total of 69 patients with NAFLD diagnosed by CT were divided into two groups by the ratio of liver spleen in CT (group A,low-grade fatty liver,n=32;group B,moderate and severe fatty liver,n=37).All patients underwent MR 3D-DIXION,1H MRS and IN/OPP examination twice within 1 week after CT examination.Fat fraction(FF) was evaluated and analyzed respectively.Results Pearson linear correlation analysis showed significant positive correlation between group A and group B about FF3D-DIXON,FFMRs and FFIN/OPP.Area under ROC curve (AUC) was different:AUCsYNTHESIZE＞AUCMRs＞AUCIN/OPP＞AUC3D-DIXON.Kruskal-Wallis H revealed significant difference among the three sequences no matter in group A or group B (P＜0.05).FF values of the three sequences (FF3D-DIXON,FFMRs and FFIN/OPP) were negatively correlated with CT liver/ spleen ratio in each group.The cut-off value of 3D-DIXON,IN/OPP and 1 H-MRS to diagnose presence or absence of fatty liver was 4.9 3 9 ％,5.2 8 4 ％ and 10.4 6 0 ％.Conclusion FF values measured by MRI methods might significantly vary based on different sequences.1 H-MRS is also the main method for quantitative assessment of fatty liver,3D-DIXON showed significant advantage in quantifying moderate and severe fatty liver.
