Correlation study between X-ray calcification and expression of human epidermal growth factor receptor-2 in breast cancer
10.3969/j.issn.1002-1671.2017.11.008
- VernacularTitle:乳腺癌X线钙化与人类表皮生长因子受体2表达的相关性研究
- Author:
Run LIU
1
;
Yan DONG
;
Junle YANG
;
Xiaoping WU
;
Mingyue MA
;
Min XU
;
Yi LI
;
Qi WANG
Author Information
1. 西安交通大学附属西安市中心医院放射科
- Keywords:
breast cancer;
calcification;
human epidermal growth factor receptor-2;
mammography
- From:
Journal of Practical Radiology
2017;33(11):1682-1684,1706
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between X-ray calcification and expression of human epidermal growth factor receptor-2 (HER-2) in breast cancer.Methods Totally 84 patients with breast cancer proved pathologically who underwent digital mammography examination before operation were collected,and HER-2 of surgical specimens were detected by immunohistochemical staining after operation.The correlation between X-ray calcification and HER-2 expression was analyzed.Results The positive expression rate and the negative expression rate of HER-2 were equal in X-ray calcified group.The negative expression rate of HER-2 was higher in the non calcified group (61.54 ％).There were no differences between the calcification type,calcification number and HER-2 expression (P＞0.05).The positive expression rate of HER-2 in calcification range ≥2 cm group was significantly higher than that in calcification range ＜2 cm group (P＜0.05).The positive expression rate of HER-2 in calcification distribution ≥2 quadrants was significantly higher than that in one quadrant group (P ＜0.01).The negative expression rate of HER-2 in cluster-like calcification was higher(61.11 ％) than that in other calcifications.Conclusion There is a certain correlation between X-ray calcification and HER-2 expression in breast cancer,which can provide a clinical reference for surgical approach and prognosis evaluation of breast cancer.
