Long-term Predictive Values of HPV Test Using Alone in Cervical Cancer Screening: A Metal Analysis
- VernacularTitle:HPV检测独立应用于宫颈癌筛查长期预测价值的Meta分析
- Author:
Shiqi HU
1
;
Yujing YANG
;
Xia ZHAO
Author Information
1. 四川大学华西第二医院出生缺陷与相关妇儿疾病教育部重点实验室发育与妇儿疾病四川省重点实验室
- Keywords:
Cervical cancer;
Human papilloma viras test;
Cytology-based screening
- From:
Journal of Practical Obstetrics and Gynecology
2018;34(5):371-376
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To further evaluate the long-term predictive value of HPV test in cervical cancer screening.Methods:To search PubMed and Web of Science databases by computer.The studies conducted HPV-based screening program and followed up for more than 3 years were included.After data extraction,the risk of cervical intraepithelial neoplasia(CIN) grade Ⅱ or worse(CIN Ⅱ +),CIN gradeⅢ or worse(CIN Ⅲ +),and cervical cancer was evaluated through the pooled cumulative incidence and odds ratio(OR) values among women with different baseline test results.Results:Finally,26 cohort studies were included.Compared to cytology negative,negative for HPV test was associated with significantly lower incidence of cervical diseases within 3 years (CIN Ⅱ +:OR =0.500,P ＜ 0.001;CIN Ⅲ+:OR =0.377,P ＜ 0.001;cervical cancer:OR =0.546,P ＜ 0.001).The 5-year pooled cumulative incidence of CIN Ⅱ +,CIN Ⅲ + and cervical cancer in HPV negative women was lower than 3-year detection rates in cytology negative women(CIN Ⅱ +:0.47％ vs 0.60％;CINⅢ +:0.15％ vs 0.20％;cervical cancer:0.016％ vs 0.020％),while the OR values had no significant difference.Conclusions:We recommend that HPV test using alone can be considered as an alternative strategy for cervical cancer screening with five-year screening interval.
