Relationship among Lymph Vascular Space Invasion with Clinicopathological Factors and Prognosis in Early Cervical Cancer
- VernacularTitle:早期宫颈癌淋巴脉管间隙浸润与临床病理因素及预后的关系
- Author:
Ying ZHOU
1
;
Jiyong JIANG
Author Information
1. 大连医科大学附属大连市妇产医院
- Keywords:
Cervical carcinoma;
Lymph vascular space invasion;
Lymph node metastasis;
Clinicopathological factors
- From:
Journal of Practical Obstetrics and Gynecology
2018;34(3):203-207
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship among lymph vascular space invasion (LVSI) with clinicopathological factors and prognosis in early cervical cancer(CC).Methods:Retrospective analysis was conducted on 280 cases of early CC that were surgically treated at Dalian Maternal and Child Health Care hospital between January 2009 and June 2012.Univariate analysis was performed to study the relationship between LVSI and clinicopathological factors,the clinicopathological factors statistically associated with LVSI in univariate analysis were studied by multivariate analysis to identify the independent risk factors of LVSI.Results:①Univariate analysis showed that histological type,histological differentiation,lymph node metastasis and cervical stromal invasion depth were significantly correlated with LVSI (P ＜ O.05).Multivariate analysis showed that LVSI was an independent risk factor for differentiation,lymph node metastasis,and the depth of invasion.②The 5-year disease free survival(DFS) of LVSI positive patients was 74％,and the overall survival(OS) was 80％.The 5-year DFS and OS of LVSI negative patients were 93％ (P ＜ 0.05).Conclusions:LVSI can reflect the potential risk of lymph node metastasis to some extent.LVSI is the independent risk factor of lymph node metastasis and can significantly reduce the DFS and OS.Patients with LVSI positive may have deeper infiltration and poorer differentiation,but more studies are needed to confirm it.
