Relationship between High-risk HPV Infection and Cervical Lsesions in Cervical Cancer Opportunistic Screening
- VernacularTitle:宫颈癌机会性筛查人群中高危型HPV感染状况及其与宫颈病变关系的研究
- Author:
Qin HAN
1
;
Hongyan GUO
;
Li GENG
Author Information
1. 北京大学第三医院
- Keywords:
Cervical cancer screening;
Human papilloma virus;
Human papilloma virus genotyping test
- From:
Journal of Practical Obstetrics and Gynecology
2018;34(3):194-197
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the infection rate of high-risk HPV(hr-HPV) and its relationship with cervical intraepithelial neoplasms in cervical cancer screening population.Methods:The positive rate of HPV 16,18 and other 12 kinds of HPV subtypes from 2015.Jun to 2016 Nov was calculated and the infection rate in CIN Ⅱ+ population were analysed.Results:In the cervical cancer screening population,the total HPV positive rate was 19.0％,the positive rate of HPV 16,HPV 18 and other 12 kinds of HPV were 5.0％,1.6％ and 15.2％ respectively The risk to develop CIN Ⅱ + in HPV 16,HPV 18 and 12 other hr-HPV positive TCT ASCUS/LSlL population was 55.2％,35.5％ and 38.9％ respectively The risk to develop CIN Ⅲ+ was 25.3％,7.7％ and 6.9％ in HPV 16,HPV 18 and other 12 kinds of hr-HPV positive TCT ASCUS/LSIL population respectively In the CIN Ⅱ + population,45.0％ cases were 12 other hr-HPV positive while 46.3％ were HPV 16 positive and the positive rate of HPV 18 was 8.7％.Conclusions:In the cervical cancer screening population,the rate of HPV 18 positive was low,the rate of other 12 kinds of HPV positive was high.It's necessary to establish exact classification for the positive rate of each subtype.hr-HPV genotyping plays an important role in cervical cancer screening.In the referral to colposcope population,the rate of HPV 18 positive was low,the TCT results showed ASCUS/LSIL risk of HPV 18 positive and other 12 kinds of HPV positive was low.Consider using shunt detection to improve screening specificity.
