Study progress in capsid protein VP1 of enterovirus 71
10.3760/cma.j.issn.2095-428X.2018.22.020
- VernacularTitle:肠道病毒71型衣壳蛋白VP1研究进展
- Author:
Yongjuan LIU
1
;
Jingyi ZHOU
;
Shaolin ZHAO
;
Li MIAO
;
Chunyan ZHANG
;
Ting ZHANG
;
Juan HUO
;
Zijin YANG
Author Information
1. 连云港市第一人民医院中心实验室
- Keywords:
Enterovirus 71;
Hand,foot and mouth disease;
Capsid protein VP1
- From:
Chinese Journal of Applied Clinical Pediatrics
2018;33(22):1755-1758
- CountryChina
- Language:Chinese
-
Abstract:
Human enterovirus 71 (EV71) is one of the major causative agent of hand,foot and mouth disease (HFMD) in infant.Clinical studies find that EV71 infection can cause a variety of clinical manifestations,from mild HFMD to fatal neurogenic pulmonary edema and even death,but the reasons remain unclear.The capsid protein VP1 of EV71 plays a key role in the processes of viral recognizing,binding and entering into the targeted cells and viral particles assembling.VP1 variation is a major determinant to EV71 fitness and immunogenicity.This study reviews the research progress of the structure,functions and associated antiviral vaccines and drugs of VP1,which further provides a theoretical basis for developing new and more effective antiviral vaccine and drugs.
