Progress in study on immune-tolerant children with chronic hepatitis B
10.3760/cma.j.issn.2095-428X.2018.22.002
- VernacularTitle:儿童慢性乙型肝炎免疫耐受期研究进展
- Author:
Shishu ZHU
1
;
Yi DONG
Author Information
1. 中国人民解放军第三○二医院青少年肝病诊疗与研究中心
- Keywords:
Chronic hepatitis B;
Immune tolerance phase;
Child;
Antiviral treatment;
Monitor
- From:
Chinese Journal of Applied Clinical Pediatrics
2018;33(22):1686-1689
- CountryChina
- Language:Chinese
-
Abstract:
The natural history of chronic hepatitis B is complex including immune-tolerant phase,immune clearance phase,inactive carrier phase and reactivation phase,among these phases,it has not yet reached a consensus on the definition of the immune-tolerant phase,because its key immune features are not entirely sure.However,the current diagnostic criteria of this phase require normal alanine aminotransferase (ALT) levels,positive hepatitis B s antigen and e antigen,high serum hepatitis B virus DNA (HBV-DNA),and slight or normal inflammation of liver histology.Antiviral therapy in this phase is currently not recommended in all guidelines,but in recent years,antiviral treatment of immune-tolerant children achieved efficacy in several study.Nonetheless before new findings are published,it would be important to closely and regular monitor serum ALT and HBV-DNA in the immune-tolerant children.
