Localized Scleroderma-like Reaction Induced by Doxifluridine.
- Author:
Kyung Moon LEE
1
;
Ah Young CHO
;
Young LEE
;
Young Joon SEO
;
Jang Kyu PARK
;
Jeung Hoon LEE
Author Information
1. Department of Dermatology, College of Medicine, Chungnam National University, Daejeon, Korea. jhoon@cnu.ac.kr
- Publication Type:Case Report
- Keywords:
Doxifluridine;
Localized scleroderma-like reaction
- MeSH:
Antibodies, Antinuclear;
Biopsy;
Breast;
Breast Neoplasms;
Collagen;
Female;
Floxuridine;
Fluorouracil;
Humans;
Hydroxamic Acids;
Middle Aged;
Pelvis;
Reference Values;
Skin;
Subcutaneous Tissue
- From:Korean Journal of Dermatology
2009;47(1):95-97
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Exogenous factors, including environmental substances and drugs, are known to induce scleroderma-like reactions. Various scleroderma-like reactions induced by anti-cancer drugs have recently been reported. This is the first report that doxifluridine (Didox), an oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU), induced a localized sclerderma-like reaction. A 51-year-old woman was referred to our clinic with multiple pearly, shiny patches on both her breasts, her pelvis and her back. After surgical excision and radiation therapy due to her right breast cancer, she took Didox for 7 months. A skin biopsy specimen revealed that the dermal collagen thickening extended even to the subcutaneous tissue. The routine laboratory tests were within the normal ranges and the tests for antinuclear antibody (ANA), anti SS-A antibody, anti SS-B antibody and anti U1-RNP antibody were all negative. After discontinuation of Didox, the lesions gradually improved. Based on these finding, we diagnosed this case as a localized scleroderma-like reaction induced by doxifluridine and we should pay attention to detect this adverse effect of the long term use of doxifluridine.
